HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration

Arik Cooper, Mayra García, Constantinos Petrovas, Takuya Yamamoto, Richard A. Koup and Gary J. Nabel ()
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Arik Cooper: Virology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 4502, MSC-3005, 40 Convent Drive, Bethesda, Maryland 20892-3005, USA
Mayra García: Virology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 4502, MSC-3005, 40 Convent Drive, Bethesda, Maryland 20892-3005, USA
Constantinos Petrovas: Immunology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 3502, MSC-3022, 40 Convent Drive, Bethesda, Maryland 20892-3022, USA
Takuya Yamamoto: Immunology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 3502, MSC-3022, 40 Convent Drive, Bethesda, Maryland 20892-3022, USA
Richard A. Koup: Immunology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 3502, MSC-3022, 40 Convent Drive, Bethesda, Maryland 20892-3022, USA
Gary J. Nabel: Virology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 4502, MSC-3005, 40 Convent Drive, Bethesda, Maryland 20892-3005, USA

Nature, 2013, vol. 498, issue 7454, 376-379

Abstract: HIV-1 causes CD4+T-cell death through viral integration by stimulation of DNA-dependent protein kinase (DNA-PK), a protein known to act in the p53 damage response pathway for double-stranded DNA breaks, in activated cells.

Date: 2013
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DOI: 10.1038/nature12274

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