cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

Andrea Ablasser (), Marion Goldeck, Taner Cavlar, Tobias Deimling, Gregor Witte, Ingo Röhl, Karl-Peter Hopfner, Janos Ludwig and Veit Hornung ()
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Andrea Ablasser: Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany
Marion Goldeck: Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany
Taner Cavlar: Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany
Tobias Deimling: Ludwig-Maximilians-University, 81377 Munich, Germany
Gregor Witte: Ludwig-Maximilians-University, 81377 Munich, Germany
Ingo Röhl: Axolabs GmbH, 95326 Kulmbach, Germany
Karl-Peter Hopfner: Ludwig-Maximilians-University, 81377 Munich, Germany
Janos Ludwig: Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany
Veit Hornung: Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany

Nature, 2013, vol. 498, issue 7454, 380-384

Abstract: Cytosolic DNA induces type I interferon via activation of STING; the immediate STING activator is produced by the recently identified DNA sensor cGAS and is shown here to be an unorthodox cyclic dinucleotide harbouring a 2′-5′ linkage between guanosine and adenosine.

Date: 2013
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DOI: 10.1038/nature12306

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