Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

Michael T. Y. Lam, Han Cho, Hanna P. Lesch, David Gosselin, Sven Heinz, Yumiko Tanaka-Oishi, Christopher Benner, Minna U. Kaikkonen, Aneeza S. Kim, Mika Kosaka, Cindy Y. Lee, Andy Watt, Tamar R. Grossman, Michael G. Rosenfeld, Ronald M. Evans and Christopher K. Glass ()
Additional contact information
Michael T. Y. Lam: University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Han Cho: Salk Institute for Biological Studies, 10010 North Torrey Pines Road
Hanna P. Lesch: University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
David Gosselin: University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Sven Heinz: University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Yumiko Tanaka-Oishi: University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Christopher Benner: University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Minna U. Kaikkonen: University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Aneeza S. Kim: Isis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, California 92010, USA
Mika Kosaka: University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Cindy Y. Lee: University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Andy Watt: Isis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, California 92010, USA
Tamar R. Grossman: Isis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, California 92010, USA
Michael G. Rosenfeld: University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Ronald M. Evans: Salk Institute for Biological Studies, 10010 North Torrey Pines Road
Christopher K. Glass: University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA

Nature, 2013, vol. 498, issue 7455, 511-515

Abstract: It is unclear whether bidirectional non-coding RNAs transcribed from enhancer elements (eRNAs) have any functional role; here, the repressive functions of Rev-Erb nuclear receptors in macrophages are shown to be linked to their ability to inhibit the transcription of eRNAs.

Date: 2013
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DOI: 10.1038/nature12209

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