Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation

Wenbo Li, Dimple Notani, Qi Ma, Bogdan Tanasa, Esperanza Nunez, Aaron Yun Chen, Daria Merkurjev, Jie Zhang, Kenneth Ohgi, Xiaoyuan Song, Soohwan Oh, Hong-Sook Kim, Christopher K. Glass and Michael G. Rosenfeld ()
Additional contact information
Wenbo Li: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Dimple Notani: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Qi Ma: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Bogdan Tanasa: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Esperanza Nunez: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Aaron Yun Chen: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Daria Merkurjev: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Jie Zhang: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Kenneth Ohgi: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Xiaoyuan Song: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Soohwan Oh: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Hong-Sook Kim: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Christopher K. Glass: Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
Michael G. Rosenfeld: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA

Nature, 2013, vol. 498, issue 7455, 516-520

Abstract: It is unclear whether bidirectional non-coding RNAs transcribed from enhancer elements (eRNAs) have any functional role; here, eRNA transcription is shown to be functionally important during the activation of genes by the oestrogen receptor in human breast cancer cells.

Date: 2013
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DOI: 10.1038/nature12210

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