Severe malaria is associated with parasite binding to endothelial protein C receptor

Louise Turner (), Thomas Lavstsen (), Sanne S. Berger, Christian W. Wang, Jens E. V. Petersen, Marion Avril, Andrew J. Brazier, Jim Freeth, Jakob S. Jespersen, Morten A. Nielsen, Pamela Magistrado, John Lusingu, Joseph D. Smith, Matthew K. Higgins and Thor G. Theander
Additional contact information
Louise Turner: Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark
Thomas Lavstsen: Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark
Sanne S. Berger: Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark
Christian W. Wang: Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark
Jens E. V. Petersen: Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark
Marion Avril: Seattle Biomedical Research Institute
Andrew J. Brazier: Seattle Biomedical Research Institute
Jim Freeth: Retrogenix, Crown House, Bingswood Estate, Whaley Bridge, High Peak SK23 7LY, UK
Jakob S. Jespersen: Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark
Morten A. Nielsen: Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark
Pamela Magistrado: National Institute of Medical Research, Tanga Centre, Tanga, Tanzania
John Lusingu: National Institute of Medical Research, Tanga Centre, Tanga, Tanzania
Joseph D. Smith: Seattle Biomedical Research Institute
Matthew K. Higgins: University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Thor G. Theander: Centre for Medical Parasitology, Immunology & Microbiology, Rigshospitalet, Copenhagen, Denmark

Nature, 2013, vol. 498, issue 7455, 502-505

Abstract: Endothelial protein C receptor is shown to be the receptor for Plasmodium falciparum erythrocyte membrane protein 1 variants associated with severe malaria.

Date: 2013
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DOI: 10.1038/nature12216

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