In vivo cardiac reprogramming contributes to zebrafish heart regeneration

Ruilin Zhang, Peidong Han, Hongbo Yang, Kunfu Ouyang, Derek Lee, Yi-Fan Lin, Karen Ocorr, Guson Kang, Ju Chen, Didier Y. R. Stainier, Deborah Yelon and Neil C. Chi ()
Additional contact information
Ruilin Zhang: University of California, San Diego, La Jolla, California 92093, USA
Peidong Han: University of California, San Diego, La Jolla, California 92093, USA
Hongbo Yang: University of California, San Diego, La Jolla, California 92093, USA
Kunfu Ouyang: University of California, San Diego, La Jolla, California 92093, USA
Derek Lee: University of California, San Diego, La Jolla, California 92093, USA
Yi-Fan Lin: University of California, San Diego, La Jolla, California 92093, USA
Karen Ocorr: Development and Aging Program, Sanford-Burnham Institute for Medical Research, La Jolla, California 92037, USA
Guson Kang: University of California, San Francisco, San Francisco, California 94158, USA
Ju Chen: University of California, San Diego, La Jolla, California 92093, USA
Didier Y. R. Stainier: University of California, San Francisco, San Francisco, California 94158, USA
Deborah Yelon: University of California, San Diego, La Jolla, California 92093, USA
Neil C. Chi: University of California, San Diego, La Jolla, California 92093, USA

Nature, 2013, vol. 498, issue 7455, 497-501

Abstract: A cardiac injury study in zebrafish reveals the plasticity of heart cell lineages as shown by a Notch-dependent transdifferentiation of atrial to ventricular cardiomyocytes, regenerating a cell type that is damaged in human heart failure.

Date: 2013
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DOI: 10.1038/nature12322

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