Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

Masaru Kanekiyo, Chih-Jen Wei, Hadi M. Yassine, Patrick M. McTamney, Jeffrey C. Boyington, James R. R. Whittle, Srinivas S. Rao, Wing-Pui Kong, Lingshu Wang and Gary J. Nabel ()
Additional contact information
Masaru Kanekiyo: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Chih-Jen Wei: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Hadi M. Yassine: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Patrick M. McTamney: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Jeffrey C. Boyington: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
James R. R. Whittle: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Srinivas S. Rao: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Wing-Pui Kong: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Lingshu Wang: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Gary J. Nabel: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health

Nature, 2013, vol. 499, issue 7456, 102-106

Abstract: A novel platform for vaccines has been developed using self-assembling ferritin-based nanoparticles displaying influenza virus haemagglutinin; the haemagglutinin–nanoparticle vaccine induces more broad and potent neutralizing antibodies against diverse virus strains than a licensed influenza vaccine in mice and ferrets.

Date: 2013
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DOI: 10.1038/nature12202

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