ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors

Lingbo Zhang, Lina Prak, Violeta Rayon-Estrada, Prathapan Thiru, Johan Flygare, Bing Lim and Harvey F. Lodish ()
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Lingbo Zhang: Massachusetts Institute of Technology
Lina Prak: Massachusetts Institute of Technology
Violeta Rayon-Estrada: Massachusetts Institute of Technology
Prathapan Thiru: Massachusetts Institute of Technology
Johan Flygare: Massachusetts Institute of Technology
Bing Lim: Computation and Systems Biology, Singapore-Massachusetts Institute of Technology Alliance, 117576 Singapore
Harvey F. Lodish: Massachusetts Institute of Technology

Nature, 2013, vol. 499, issue 7456, 92-96

Abstract: Under stress conditions such as acute blood loss or chronic anaemia, glucocorticoids trigger self-renewal of early burst-forming unit–erythroid (BFU–E) progenitors in the spleen, however, the mechanism of glucocorticoid action is not well understood; here the RNA binding protein ZFP36L2 is identified as a transcriptional target of the glucocorticoid receptor in BFU-Es and is shown to be involved in the process of erythroid cell expansion following exposure to glucocorticoids.

Date: 2013
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DOI: 10.1038/nature12215

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