Variation and genetic control of protein abundance in humans

Linfeng Wu, Sophie I. Candille, Yoonha Choi, Dan Xie, Lihua Jiang, Jennifer Li-Pook-Than, Hua Tang () and Michael Snyder ()
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Linfeng Wu: Stanford University School of Medicine
Sophie I. Candille: Stanford University School of Medicine
Yoonha Choi: Stanford University School of Medicine
Dan Xie: Stanford University School of Medicine
Lihua Jiang: Stanford University School of Medicine
Jennifer Li-Pook-Than: Stanford University School of Medicine
Hua Tang: Stanford University School of Medicine
Michael Snyder: Stanford University School of Medicine

Nature, 2013, vol. 499, issue 7456, 79-82

Abstract: A large-scale analysis of variation in human protein levels between individuals is performed using mass-spectrometry-based proteomic technology, and a number of protein quantitative trait loci are identified; over 5% of proteins vary by more than 1.5-fold in their expression levels between individuals, and this variation is not always linked to RNA level.

Date: 2013
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DOI: 10.1038/nature12223

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