Structural basis for alternating access of a eukaryotic calcium/proton exchanger

Andrew B. Waight, Bjørn Panyella Pedersen, Avner Schlessinger, Massimiliano Bonomi, Bryant H. Chau, Zygy Roe-Zurz, Aaron J. Risenmay, Andrej Sali and Robert M. Stroud ()
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Andrew B. Waight: University of California
Bjørn Panyella Pedersen: University of California
Avner Schlessinger: California Institute for Quantitative Biosciences, University of California
Massimiliano Bonomi: California Institute for Quantitative Biosciences, University of California
Bryant H. Chau: University of California
Zygy Roe-Zurz: University of California
Aaron J. Risenmay: University of California
Andrej Sali: California Institute for Quantitative Biosciences, University of California
Robert M. Stroud: University of California

Nature, 2013, vol. 499, issue 7456, 107-110

Abstract: The X-ray crystal structure of a member of the Ca2+/H+ (CAX) antiporter family from Saccharomyces cerevisiae in a cytosol-facing, substrate-bound conformation is solved; using the structure, a mechanism by which members of the Ca2+:cation (CaCA) superfamily facilitate Ca2+ transport across cellular membranes is proposed.

Date: 2013
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DOI: 10.1038/nature12233

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