Mutational heterogeneity in cancer and the search for new cancer-associated genes

Michael S. Lawrence, Petar Stojanov, Paz Polak, Gregory V. Kryukov, Kristian Cibulskis, Andrey Sivachenko, Scott L. Carter, Chip Stewart, Craig H. Mermel, Steven A. Roberts, Adam Kiezun, Peter S. Hammerman, Aaron McKenna, Yotam Drier, Lihua Zou, Alex H. Ramos, Trevor J. Pugh, Nicolas Stransky, Elena Helman, Jaegil Kim, Carrie Sougnez, Lauren Ambrogio, Elizabeth Nickerson, Erica Shefler, Maria L. Cortés, Daniel Auclair, Gordon Saksena, Douglas Voet, Michael Noble, Daniel DiCara, Pei Lin, Lee Lichtenstein, David I. Heiman, Timothy Fennell, Marcin Imielinski, Bryan Hernandez, Eran Hodis, Sylvan Baca, Austin M. Dulak, Jens Lohr, Dan-Avi Landau, Catherine J. Wu, Jorge Melendez-Zajgla, Alfredo Hidalgo-Miranda, Amnon Koren, Steven A. McCarroll, Jaume Mora, Ryan S. Lee, Brian Crompton, Robert Onofrio, Melissa Parkin, Wendy Winckler, Kristin Ardlie, Stacey B. Gabriel, Charles W. M. Roberts, Jaclyn A. Biegel, Kimberly Stegmaier, Adam J. Bass, Levi A. Garraway, Matthew Meyerson, Todd R. Golub, Dmitry A. Gordenin, Shamil Sunyaev, Eric S. Lander () and Gad Getz ()
Additional contact information
Michael S. Lawrence: The Broad Institute of MIT and Harvard
Petar Stojanov: The Broad Institute of MIT and Harvard
Paz Polak: The Broad Institute of MIT and Harvard
Gregory V. Kryukov: The Broad Institute of MIT and Harvard
Kristian Cibulskis: The Broad Institute of MIT and Harvard
Andrey Sivachenko: The Broad Institute of MIT and Harvard
Scott L. Carter: The Broad Institute of MIT and Harvard
Chip Stewart: The Broad Institute of MIT and Harvard
Craig H. Mermel: The Broad Institute of MIT and Harvard
Steven A. Roberts: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Durham, North Carolina 27709, USA
Adam Kiezun: The Broad Institute of MIT and Harvard
Peter S. Hammerman: The Broad Institute of MIT and Harvard
Aaron McKenna: The Broad Institute of MIT and Harvard
Yotam Drier: The Broad Institute of MIT and Harvard
Lihua Zou: The Broad Institute of MIT and Harvard
Alex H. Ramos: The Broad Institute of MIT and Harvard
Trevor J. Pugh: The Broad Institute of MIT and Harvard
Nicolas Stransky: The Broad Institute of MIT and Harvard
Elena Helman: The Broad Institute of MIT and Harvard
Jaegil Kim: The Broad Institute of MIT and Harvard
Carrie Sougnez: The Broad Institute of MIT and Harvard
Lauren Ambrogio: The Broad Institute of MIT and Harvard
Elizabeth Nickerson: The Broad Institute of MIT and Harvard
Erica Shefler: The Broad Institute of MIT and Harvard
Maria L. Cortés: The Broad Institute of MIT and Harvard
Daniel Auclair: The Broad Institute of MIT and Harvard
Gordon Saksena: The Broad Institute of MIT and Harvard
Douglas Voet: The Broad Institute of MIT and Harvard
Michael Noble: The Broad Institute of MIT and Harvard
Daniel DiCara: The Broad Institute of MIT and Harvard
Pei Lin: The Broad Institute of MIT and Harvard
Lee Lichtenstein: The Broad Institute of MIT and Harvard
David I. Heiman: The Broad Institute of MIT and Harvard
Timothy Fennell: The Broad Institute of MIT and Harvard
Marcin Imielinski: The Broad Institute of MIT and Harvard
Bryan Hernandez: The Broad Institute of MIT and Harvard
Eran Hodis: The Broad Institute of MIT and Harvard
Sylvan Baca: The Broad Institute of MIT and Harvard
Austin M. Dulak: The Broad Institute of MIT and Harvard
Jens Lohr: The Broad Institute of MIT and Harvard
Dan-Avi Landau: The Broad Institute of MIT and Harvard
Catherine J. Wu: Dana-Farber Cancer Institute
Jorge Melendez-Zajgla: Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico
Alfredo Hidalgo-Miranda: Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico
Amnon Koren: The Broad Institute of MIT and Harvard
Steven A. McCarroll: The Broad Institute of MIT and Harvard
Jaume Mora: Hospital Sant Joan de Déu, Barcelona 08950, Spain
Ryan S. Lee: Dana-Farber Cancer Institute
Brian Crompton: Dana-Farber Cancer Institute
Robert Onofrio: The Broad Institute of MIT and Harvard
Melissa Parkin: The Broad Institute of MIT and Harvard
Wendy Winckler: The Broad Institute of MIT and Harvard
Kristin Ardlie: The Broad Institute of MIT and Harvard
Stacey B. Gabriel: The Broad Institute of MIT and Harvard
Charles W. M. Roberts: Dana-Farber Cancer Institute
Jaclyn A. Biegel: Children’s Hospital
Kimberly Stegmaier: The Broad Institute of MIT and Harvard
Adam J. Bass: The Broad Institute of MIT and Harvard
Levi A. Garraway: The Broad Institute of MIT and Harvard
Matthew Meyerson: The Broad Institute of MIT and Harvard
Todd R. Golub: The Broad Institute of MIT and Harvard
Dmitry A. Gordenin: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Durham, North Carolina 27709, USA
Shamil Sunyaev: The Broad Institute of MIT and Harvard
Eric S. Lander: The Broad Institute of MIT and Harvard
Gad Getz: The Broad Institute of MIT and Harvard

Nature, 2013, vol. 499, issue 7457, 214-218

Abstract: As the sample size in cancer genome studies increases, the list of genes identified as significantly mutated is likely to include more false positives; here, this problem is identified as stemming largely from mutation heterogeneity, and a new analytical methodology designed to overcome this problem is described.

Date: 2013
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DOI: 10.1038/nature12213

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