Wnt activation in nail epithelium couples nail growth to digit regeneration

Makoto Takeo, Wei Chin Chou, Qi Sun, Wendy Lee, Piul Rabbani, Cynthia Loomis, M. Mark Taketo and Mayumi Ito ()
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Makoto Takeo: New York University, School of Medicine
Wei Chin Chou: New York University, School of Medicine
Qi Sun: New York University, School of Medicine
Wendy Lee: New York University, School of Medicine
Piul Rabbani: New York University, School of Medicine
Cynthia Loomis: New York University, School of Medicine
M. Mark Taketo: Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan
Mayumi Ito: New York University, School of Medicine

Nature, 2013, vol. 499, issue 7457, 228-232

Abstract: Nail stem cells (NSCs) reside in the proximal nail matrix, and early nail progenitors undergo Wnt-dependent differentiation into the nail; after amputation, Wnt activation is required for nail and digit regeneration, and amputations proximal to the Wnt-active nail progenitors fail to regenerate, but β-catenin stabilization in the NSC region induces regeneration.

Date: 2013
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DOI: 10.1038/nature12214

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