An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry

Sonia Sharma, Ariel Quintana, Gregory M. Findlay, Marcel Mettlen, Beate Baust, Mohit Jain, Roland Nilsson, Anjana Rao () and Patrick G. Hogan ()
Additional contact information
Sonia Sharma: La Jolla Institute for Allergy and Immunology
Ariel Quintana: La Jolla Institute for Allergy and Immunology
Gregory M. Findlay: Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School
Marcel Mettlen: The Scripps Research Institute
Beate Baust: Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School
Mohit Jain: Broad Institute
Roland Nilsson: Karolinska Institute
Anjana Rao: La Jolla Institute for Allergy and Immunology
Patrick G. Hogan: La Jolla Institute for Allergy and Immunology

Nature, 2013, vol. 499, issue 7457, 238-242

Abstract: A genome-wide RNA interference analysis identifies the septin family of cytoskeletal filaments as important regulators of store-operated Ca2+ entry into the cell; septins are shown to organize plasma membrane microdomains important in STIM1 and ORAI1 signalling, and may also be relevant in membrane microdomains underlying other signalling processes.

Date: 2013
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DOI: 10.1038/nature12229

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