PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum

Lubin Jiang (), Jianbing Mu, Qingfeng Zhang, Ting Ni, Prakash Srinivasan, Kempaiah Rayavara, Wenjing Yang, Louise Turner, Thomas Lavstsen, Thor G. Theander, Weiqun Peng, Guiying Wei, Qingqing Jing, Yoshiyuki Wakabayashi, Abhisheka Bansal, Yan Luo, José M. C. Ribeiro, Artur Scherf, L. Aravind, Jun Zhu, Keji Zhao and Louis H. Miller ()
Additional contact information
Lubin Jiang: Key Laboratory of Molecular Virology & Immunology, Unit of Human Parasite Molecular and Cell Biology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
Jianbing Mu: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Qingfeng Zhang: Institute of Infectious Diseases and Vaccine Development, Tongji University School of Medicine
Ting Ni: State Key Laboratory of Genetics Engineering & MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University
Prakash Srinivasan: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Kempaiah Rayavara: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Wenjing Yang: Genetics and Development Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Louise Turner: Centre for Medical Parasitology, Immunology & Microbiology, Faculty of Health Sciences, Copenhagen University Hospital (Rigshospitalet), 1014 Copenhagen, Denmark
Thomas Lavstsen: Centre for Medical Parasitology, Immunology & Microbiology, Faculty of Health Sciences, Copenhagen University Hospital (Rigshospitalet), 1014 Copenhagen, Denmark
Thor G. Theander: Centre for Medical Parasitology, Immunology & Microbiology, Faculty of Health Sciences, Copenhagen University Hospital (Rigshospitalet), 1014 Copenhagen, Denmark
Weiqun Peng: George Washington University, 725 21st Street NW, Washington, DC 20052, USA
Guiying Wei: Institute of Infectious Diseases and Vaccine Development, Tongji University School of Medicine
Qingqing Jing: Key Laboratory of Molecular Virology & Immunology, Unit of Human Parasite Molecular and Cell Biology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
Yoshiyuki Wakabayashi: Genetics and Development Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Abhisheka Bansal: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Yan Luo: Genetics and Development Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
José M. C. Ribeiro: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Artur Scherf: Institut Pasteur, Unité de Biologie des Interactions Hôte-Parasite, F-75015 Paris, France
L. Aravind: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health
Jun Zhu: Genetics and Development Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Keji Zhao: Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Louis H. Miller: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health

Nature, 2013, vol. 499, issue 7457, 223-227

Abstract: The malaria parasite Plasmodium falciparum escapes immune detection by expressing one of 60 antigenically distinct var genes at any one time during the course of infection: here it is shown that the P. falciparum protein PfSETvs has a key role in var gene silencing through the trimethylation of histone H3K36.

Date: 2013
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DOI: 10.1038/nature12361

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