High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat

Xiao Tian, Jorge Azpurua, Christopher Hine, Amita Vaidya, Max Myakishev-Rempel, Julia Ablaeva, Zhiyong Mao, Eviatar Nevo, Vera Gorbunova () and Andrei Seluanov ()
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Xiao Tian: University of Rochester
Jorge Azpurua: University of Rochester
Christopher Hine: University of Rochester
Amita Vaidya: University of Rochester
Max Myakishev-Rempel: University of Rochester
Julia Ablaeva: University of Rochester
Zhiyong Mao: University of Rochester
Eviatar Nevo: Institute of Evolution, University of Haifa
Vera Gorbunova: University of Rochester
Andrei Seluanov: University of Rochester

Nature, 2013, vol. 499, issue 7458, 346-349

Abstract: Naked mole rats seem almost entirely protected from developing cancer, and this can now, at least in part, be explained by the production of a unique high-molecular-mass form of hyaluronan, a component of the extracellular matrix; together with an increased sensitivity of naked mole-rat cells to hyaluronan signalling, this form protects its cells from oncogenic transformation.

Date: 2013
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DOI: 10.1038/nature12234

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