Promoter directionality is controlled by U1 snRNP and polyadenylation signals

Albert E. Almada, Xuebing Wu, Andrea J. Kriz, Christopher B. Burge and Phillip A. Sharp ()
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Albert E. Almada: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Xuebing Wu: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Andrea J. Kriz: Massachusetts Institute of Technology
Christopher B. Burge: Massachusetts Institute of Technology
Phillip A. Sharp: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology

Nature, 2013, vol. 499, issue 7458, 360-363

Abstract: Asymmetric sequence determinants flanking gene transcription start sites are shown to control directionality of transcription elongation in mammalian cells by regulating promoter-proximal cleavage and polyadenylation.

Date: 2013
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DOI: 10.1038/nature12349

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