Structure and function of the Salmonella Typhi chimaeric A2B5 typhoid toxin

Jeongmin Song, Xiang Gao and Jorge E. Galán ()
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Jeongmin Song: Yale University School of Medicine
Xiang Gao: Yale University School of Medicine
Jorge E. Galán: Yale University School of Medicine

Nature, 2013, vol. 499, issue 7458, 350-354

Abstract: Unlike most salmonellae, Salmonella enterica serovar Typhi causes life-threatening systemic infections known as typhoid fever, for which the molecular basis is unknown; here administration of typhoid toxin produced by S. Typhi reproduces many of the acute symptoms of typhoid fever, carbohydrates on cell surface glycoproteins are identified as receptors for typhoid toxin and the toxin’s crystal structure is determined, providing insights into these interactions.

Date: 2013
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DOI: 10.1038/nature12377

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