mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

Hu Zeng, Kai Yang, Caryn Cloer, Geoffrey Neale, Peter Vogel and Hongbo Chi ()
Additional contact information
Hu Zeng: St Jude Children’s Research Hospital
Kai Yang: St Jude Children’s Research Hospital
Caryn Cloer: St Jude Children’s Research Hospital
Geoffrey Neale: Hartwell Center for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital
Peter Vogel: St Jude Children’s Research Hospital
Hongbo Chi: St Jude Children’s Research Hospital

Nature, 2013, vol. 499, issue 7459, 485-490

Abstract: Here, mTORC1-dependent lipogenic programming is shown to be important for regulatory T-cell function, in part through the upregulation of the effector molecules CTLA4 and ICOS.

Date: 2013
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DOI: 10.1038/nature12297

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