Receptor binding by an H7N9 influenza virus from humans

Xiaoli Xiong, Stephen R. Martin, Lesley F. Haire, Stephen A. Wharton, Rodney S. Daniels, Michael S. Bennett, John W. McCauley, Patrick J. Collins, Philip A. Walker, John J. Skehel () and Steven J. Gamblin ()
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Xiaoli Xiong: MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
Stephen R. Martin: MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
Lesley F. Haire: MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
Stephen A. Wharton: WHO Collaborating Centre for Reference and Research on Influenza, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
Rodney S. Daniels: WHO Collaborating Centre for Reference and Research on Influenza, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
Michael S. Bennett: WHO Collaborating Centre for Reference and Research on Influenza, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
John W. McCauley: WHO Collaborating Centre for Reference and Research on Influenza, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
Patrick J. Collins: MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
Philip A. Walker: MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
John J. Skehel: MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
Steven J. Gamblin: MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK

Nature, 2013, vol. 499, issue 7459, 496-499

Abstract: An examination of the receptor-binding properties of the H7N9 virus, which has recently emerged in China, shows that the virus has acquired the ability to bind the human α-2,6-linked sialic acid receptor while retaining binding to the avian α-2,3-linked receptor, and therefore does not have the preference for human versus avian receptors characteristic of pandemic viruses.

Date: 2013
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DOI: 10.1038/nature12372

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