A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis

Xiao-Jian Sun, Zhanxin Wang, Lan Wang, Yanwen Jiang, Nils Kost, T. David Soong, Wei-Yi Chen, Zhanyun Tang, Tomoyoshi Nakadai, Olivier Elemento, Wolfgang Fischle, Ari Melnick, Dinshaw J. Patel, Stephen D. Nimer and Robert G. Roeder ()
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Xiao-Jian Sun: Laboratory of Biochemistry and Molecular Biology, The Rockefeller University
Zhanxin Wang: Structural Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center
Lan Wang: Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center
Yanwen Jiang: Weill Cornell Medical College, New York, New York 10065, USA
Nils Kost: Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany
T. David Soong: Institute for Computational Biomedicine, Weill Cornell Medical College
Wei-Yi Chen: Laboratory of Biochemistry and Molecular Biology, The Rockefeller University
Zhanyun Tang: Laboratory of Biochemistry and Molecular Biology, The Rockefeller University
Tomoyoshi Nakadai: Laboratory of Biochemistry and Molecular Biology, The Rockefeller University
Olivier Elemento: Institute for Computational Biomedicine, Weill Cornell Medical College
Wolfgang Fischle: Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany
Ari Melnick: Weill Cornell Medical College, New York, New York 10065, USA
Dinshaw J. Patel: Structural Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center
Stephen D. Nimer: Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center
Robert G. Roeder: Laboratory of Biochemistry and Molecular Biology, The Rockefeller University

Nature, 2013, vol. 500, issue 7460, 93-97

Abstract: A multiprotein complex containing AML1–ETO, the most common fusion protein found in acute myeloid leukaemia, is revealed and analysed in leukaemic cells, and a novel, functionally important protein-binding interface is identified.

Date: 2013
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DOI: 10.1038/nature12287

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