AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes

Ritu Kumar, Lauren DiMenna, Nadine Schrode, Ting-Chun Liu, Philipp Franck, Silvia Muñoz-Descalzo, Anna-Katerina Hadjantonakis, Ali A. Zarrin, Jayanta Chaudhuri, Olivier Elemento and Todd Evans ()
Additional contact information
Ritu Kumar: Weill Cornell Medical College
Lauren DiMenna: Immunology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Institute
Nadine Schrode: Developmental Biology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Institute
Ting-Chun Liu: Weill Cornell Medical College
Philipp Franck: Weill Cornell Medical College
Silvia Muñoz-Descalzo: Developmental Biology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Institute
Anna-Katerina Hadjantonakis: Developmental Biology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Institute
Ali A. Zarrin: Genentech
Jayanta Chaudhuri: Immunology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Institute
Olivier Elemento: Institute for Computational Biomedicine, Weill Cornell Medical College
Todd Evans: Weill Cornell Medical College

Nature, 2013, vol. 500, issue 7460, 89-92

Abstract: Fibroblasts deficient in the activation-induced cytidine deaminase (AID) enzyme are shown to fail to stabilize in the pluripotent state, despite initiating the expression of pluripotency genes.

Date: 2013
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DOI: 10.1038/nature12299

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