Unusual base pairing during the decoding of a stop codon by the ribosome

Israel S. Fernández, Chyan Leong Ng, Ann C. Kelley, Guowei Wu, Yi-Tao Yu () and V. Ramakrishnan ()
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Israel S. Fernández: MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
Chyan Leong Ng: MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
Ann C. Kelley: MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
Guowei Wu: University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Yi-Tao Yu: University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
V. Ramakrishnan: MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK

Nature, 2013, vol. 500, issue 7460, 107-110

Abstract: Here, the structure of the 30S ribosomal subunit and the 70S ribosome in complex with a messenger RNA with pseudouridine in the place of uridine reveals unexpected base pairing.

Date: 2013
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DOI: 10.1038/nature12302

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