The molecular logic for planarian regeneration along the anterior–posterior axis

Yoshihiko Umesono (), Junichi Tasaki, Yui Nishimura, Martina Hrouda, Eri Kawaguchi, Shigenobu Yazawa, Osamu Nishimura, Kazutaka Hosoda, Takeshi Inoue and Kiyokazu Agata
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Yoshihiko Umesono: RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan
Junichi Tasaki: Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan
Yui Nishimura: Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan
Martina Hrouda: Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan
Eri Kawaguchi: Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan
Shigenobu Yazawa: Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan
Osamu Nishimura: Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan
Kazutaka Hosoda: Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan
Takeshi Inoue: Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan
Kiyokazu Agata: Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan

Nature, 2013, vol. 500, issue 7460, 73-76

Abstract: More than a century ago, Thomas Hunt Morgan attempted to explain the extraordinary regenerative ability of planarians such as Dugesia japonica, which can regenerate a complete individual even from a tail fragment, by proposing that two opposing morphogenetic gradients along the anterior–posterior axis are required for regeneration; here ERK and β-catenin signalling are shown to form these gradients.

Date: 2013
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DOI: 10.1038/nature12359

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