Restoration of anterior regeneration in a planarian with limited regenerative ability

James M. Sikes () and Phillip A. Newmark
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James M. Sikes: University of Illinois at Urbana-Champaign
Phillip A. Newmark: University of Illinois at Urbana-Champaign

Nature, 2013, vol. 500, issue 7460, 77-80

Abstract: Although the capacity for tissue regeneration of planarians is exceptional, planarians with more limited regenerative capacities are known; this study of Procotyla fluviatilis, a planarian with restricted ability to replace missing tissues, shows that Wnt signalling is aberrantly regulated in regeneration-deficient tissues and that downregulation of Wnt signalling in these regions restores regenerative abilities, revealing that manipulating a single signalling pathway can reverse the evolutionary loss of regenerative potential.

Date: 2013
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DOI: 10.1038/nature12403

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