Reactivating head regrowth in a regeneration-deficient planarian species

S.-Y. Liu, C. Selck, B. Friedrich, R. Lutz, M. Vila-Farré, A. Dahl, H. Brandl, N. Lakshmanaperumal, I. Henry and J. C. Rink ()
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S.-Y. Liu: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany
C. Selck: DFG-Center for Regenerative Therapies Dresden (CRTD), Cluster of Excellence, Technische Universität Dresden, Fetscherstrasse 105, 01307 Dresden, Germany
B. Friedrich: DFG-Center for Regenerative Therapies Dresden (CRTD), Cluster of Excellence, Technische Universität Dresden, Fetscherstrasse 105, 01307 Dresden, Germany
R. Lutz: DFG-Center for Regenerative Therapies Dresden (CRTD), Cluster of Excellence, Technische Universität Dresden, Fetscherstrasse 105, 01307 Dresden, Germany
M. Vila-Farré: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany
A. Dahl: Deep Sequencing Group-SFB655, DFG-Center for Regenerative Therapies Dresden (CRTD), Cluster of Excellence, Biotechnology Center (Biotec), Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany
H. Brandl: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany
N. Lakshmanaperumal: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany
I. Henry: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany
J. C. Rink: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany

Nature, 2013, vol. 500, issue 7460, 81-84

Abstract: Although the capacity for tissue regeneration of planarians is exceptional, planarians with more limited regenerative capacities are known; here knocking down components of the Wnt signalling pathway rescues head regeneration in the regeneration-impaired planarian Dendrocoelum lacteum, revealing that manipulating a single signalling pathway can reverse the evolutionary loss of regenerative potential.

Date: 2013
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DOI: 10.1038/nature12414

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