The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line

Andrew Adey (), Joshua N. Burton, Jacob O. Kitzman, Joseph B. Hiatt, Alexandra P. Lewis, Beth K. Martin, Ruolan Qiu, Choli Lee and Jay Shendure ()
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Andrew Adey: University of Washington
Joshua N. Burton: University of Washington
Jacob O. Kitzman: University of Washington
Joseph B. Hiatt: University of Washington
Alexandra P. Lewis: University of Washington
Beth K. Martin: University of Washington
Ruolan Qiu: University of Washington
Choli Lee: University of Washington
Jay Shendure: University of Washington

Nature, 2013, vol. 500, issue 7461, 207-211

Abstract: Haplotype-resolved whole-genome sequencing of the HeLa CCL-2 strain shows that HeLa is relatively stable in terms of point variation; integration of several data sets reveals strong, haplotype-specific activation of the proto-oncogene MYC by the human papilloma virus type 18 genome, and enables the relationship between gene dosage and expression to be examined.

Date: 2013
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DOI: 10.1038/nature12064

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