Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26

Guangwen Lu, Yawei Hu, Qihui Wang, Jianxun Qi, Feng Gao, Yan Li, Yanfang Zhang, Wei Zhang, Yuan Yuan, Jinku Bao, Buchang Zhang, Yi Shi, Jinghua Yan and George F. Gao ()
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Guangwen Lu: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Yawei Hu: School of Life Sciences, Anhui University
Qihui Wang: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Jianxun Qi: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Feng Gao: Laboratory of Non-coding RNA, Institute of Biophysics, Chinese Academy of Sciences
Yan Li: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Yanfang Zhang: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Wei Zhang: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Yuan Yuan: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Jinku Bao: School of Life Sciences, Sichuan University, Chengdu 610064, Sichuan, China
Buchang Zhang: School of Life Sciences, Anhui University
Yi Shi: Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences
Jinghua Yan: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
George F. Gao: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences

Nature, 2013, vol. 500, issue 7461, 227-231

Abstract: MERS-CoV is a newly emerged coronavirus that is related to SARS-CoV and has proven fatal in half of the people it has infected to date: here the crystal structure of the MERS-CoV receptor binding domain is presented in complex with its receptor on human cells, CD26.

Date: 2013
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DOI: 10.1038/nature12328

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