Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

Kathryn Blaschke, Kevin T. Ebata, Mohammad M. Karimi, Jorge A. Zepeda-Martínez, Preeti Goyal, Sahasransu Mahapatra, Angela Tam, Diana J. Laird, Martin Hirst, Anjana Rao, Matthew C. Lorincz () and Miguel Ramalho-Santos ()
Additional contact information
Kathryn Blaschke: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, 35 Medical Center Way
Kevin T. Ebata: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, 35 Medical Center Way
Mohammad M. Karimi: Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Jorge A. Zepeda-Martínez: La Jolla Institute for Allergy and Immunology and Sanford Consortium for Regenerative Medicine
Preeti Goyal: Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Sahasransu Mahapatra: La Jolla Institute for Allergy and Immunology and Sanford Consortium for Regenerative Medicine
Angela Tam: BC Cancer Agency, Canada’s Michael Smith Genome Sciences Centre, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Diana J. Laird: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, 35 Medical Center Way
Martin Hirst: BC Cancer Agency, Canada’s Michael Smith Genome Sciences Centre, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Anjana Rao: La Jolla Institute for Allergy and Immunology and Sanford Consortium for Regenerative Medicine
Matthew C. Lorincz: Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Miguel Ramalho-Santos: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, 35 Medical Center Way

Nature, 2013, vol. 500, issue 7461, 222-226

Abstract: Vitamin C is a direct regulator of Tet enzyme activity and DNA methylation fidelity in mouse ES cells; addition of vitamin C promotes Tet activity, increases 5-hydroxymethlycytosine (5hmC) and DNA demethylation of many gene promoters, upregulates demethylated germline genes, and induces a state that more closely approximates that of the inner cell mass of the blastocyst.

Date: 2013
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DOI: 10.1038/nature12362

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