Pyrimidine homeostasis is accomplished by directed overflow metabolism

Marshall Louis Reaves, Brian D. Young, Aaron M. Hosios, Yi-Fan Xu and Joshua D. Rabinowitz ()
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Marshall Louis Reaves: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Brian D. Young: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Aaron M. Hosios: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Yi-Fan Xu: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Joshua D. Rabinowitz: Lewis-Sigler Institute for Integrative Genomics, Princeton University

Nature, 2013, vol. 500, issue 7461, 237-241

Abstract: Here, the authors identify a previously unknown regulatory strategy used by Escherichia coli to control end-product levels of the pyrimidine biosynthetic pathway: this involves feedback regulation of the near-terminal pathway enzyme UMP kinase, with accumulation of UMP prevented by its degradation to uridine through UmpH, a phosphatase with a previously unknown function.

Date: 2013
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DOI: 10.1038/nature12445

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