Maternal imprinting at the H19–Igf2 locus maintains adult haematopoietic stem cell quiescence

Aparna Venkatraman, Xi C. He, Joanne L. Thorvaldsen, Ryohichi Sugimura, John M. Perry, Fang Tao, Meng Zhao, Matthew K. Christenson, Rebeca Sanchez, Jaclyn Y. Yu, Lai Peng, Jeffrey S. Haug, Ariel Paulson, Hua Li, Xiao-bo Zhong, Thomas L. Clemens, Marisa S. Bartolomei and Linheng Li ()
Additional contact information
Aparna Venkatraman: Stowers Institute for Medical Research
Xi C. He: Stowers Institute for Medical Research
Joanne L. Thorvaldsen: University of Pennsylvania
Ryohichi Sugimura: Stowers Institute for Medical Research
John M. Perry: Stowers Institute for Medical Research
Fang Tao: Stowers Institute for Medical Research
Meng Zhao: Stowers Institute for Medical Research
Matthew K. Christenson: Stowers Institute for Medical Research
Rebeca Sanchez: Stowers Institute for Medical Research
Jaclyn Y. Yu: Stowers Institute for Medical Research
Lai Peng: Toxicology & Therapeutics, University of Kansas Medical Center
Jeffrey S. Haug: Stowers Institute for Medical Research
Ariel Paulson: Stowers Institute for Medical Research
Hua Li: Stowers Institute for Medical Research
Xiao-bo Zhong: Toxicology & Therapeutics, University of Kansas Medical Center
Thomas L. Clemens: Center for Musculoskeletal Research, Johns Hopkins Medicine
Marisa S. Bartolomei: University of Pennsylvania
Linheng Li: Stowers Institute for Medical Research

Nature, 2013, vol. 500, issue 7462, 345-349

Abstract: Maternal genomic imprinting is crucial for the maintenance of adult stem cells, which is accomplished by maintaining long-term haematopoietic stem cell quiescence.

Date: 2013
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DOI: 10.1038/nature12303

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