An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways

Takashi Hirose and H. Robert Horvitz ()
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Takashi Hirose: Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
H. Robert Horvitz: Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA

Nature, 2013, vol. 500, issue 7462, 354-358

Abstract: Removal of cells during development in Caenorhabditis elegans requires the precise execution of cell-death programs, which can include both caspase-dependent and -independent pathways; here it is shown that a single upstream transcription factor can drive both, in parallel, to destroy a single cell.

Date: 2013
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DOI: 10.1038/nature12329

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