Epithelial junctions maintain tissue architecture by directing planar spindle orientation

Yu-ichiro Nakajima, Emily J. Meyer, Amanda Kroesen, Sean A. McKinney and Matthew C. Gibson ()
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Yu-ichiro Nakajima: Stowers Institute for Medical Research, 1000 East 50th Street
Emily J. Meyer: Stowers Institute for Medical Research, 1000 East 50th Street
Amanda Kroesen: Stowers Institute for Medical Research, 1000 East 50th Street
Sean A. McKinney: Stowers Institute for Medical Research, 1000 East 50th Street
Matthew C. Gibson: Stowers Institute for Medical Research, 1000 East 50th Street

Nature, 2013, vol. 500, issue 7462, 359-362

Abstract: The Drosophila tumour suppressors Scribbled and Discs large 1 are found to be essential regulators of planar spindle alignment during epithelial cell division; aberrant effects of spindle alignment are shown to be corrected through apoptosis, and the suppression of this mechanism can result in epithelial dysplasia and tumorigenesis.

Date: 2013
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DOI: 10.1038/nature12335

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