Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA

Jinwei Zhang and Adrian R. Ferré-D’Amaré ()
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Jinwei Zhang: National Heart, Lung and Blood Institute, 50 South Drive, MSC 8012, Bethesda, Maryland 20892-8012, USA
Adrian R. Ferré-D’Amaré: National Heart, Lung and Blood Institute, 50 South Drive, MSC 8012, Bethesda, Maryland 20892-8012, USA

Nature, 2013, vol. 500, issue 7462, 363-366

Abstract: The co-crystal structure of the T-box tRNA-binding region, stem I, bound to tRNA is solved, showing that this region not only binds the anticodon, but also cradles the entire tRNA, forming an extended interface; the two T-loop motifs of stem I mediate interactions similar to those of RNase P and the large ribosomal subunit, even though the three species do not share a common evolutionary ancestor.

Date: 2013
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DOI: 10.1038/nature12440

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