Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

Dhirendra K. Simanshu, Ravi Kanth Kamlekar, Dayanjan S. Wijesinghe, Xianqiong Zou, Xiuhong Zhai, Shrawan K. Mishra, Julian G. Molotkovsky, Lucy Malinina, Edward H. Hinchcliffe (), Charles E. Chalfant (), Rhoderick E. Brown () and Dinshaw J. Patel ()
Additional contact information
Dhirendra K. Simanshu: Structural Biology Program, Memorial Sloan-Kettering Cancer Center
Ravi Kanth Kamlekar: Hormel Institute, University of Minnesota
Dayanjan S. Wijesinghe: Virginia Commonwealth University
Xianqiong Zou: Hormel Institute, University of Minnesota
Xiuhong Zhai: Hormel Institute, University of Minnesota
Shrawan K. Mishra: Hormel Institute, University of Minnesota
Julian G. Molotkovsky: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Lucy Malinina: Structural Biology Unit, CIC bioGUNE, Technology Park of Bizkaia, 48160 Derio-Bilbao, Spain
Edward H. Hinchcliffe: Hormel Institute, University of Minnesota
Charles E. Chalfant: Virginia Commonwealth University
Rhoderick E. Brown: Hormel Institute, University of Minnesota
Dinshaw J. Patel: Structural Biology Program, Memorial Sloan-Kettering Cancer Center

Nature, 2013, vol. 500, issue 7463, 463-467

Abstract: A human lipid transfer protein (GLTPD1, named here CPTP) is shown to regulate eicosanoid production by mediating the intermembrane transfer of the phosphorylated sphingolipid ceramide-1-phosphate through a non-vesicular transport mechanism elucidated by structural, functional and biological data.

Date: 2013
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DOI: 10.1038/nature12332

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