DNA unwinding heterogeneity by RecBCD results from static molecules able to equilibrate

Bian Liu, Ronald J. Baskin and Stephen C. Kowalczykowski ()
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Bian Liu: University of California, Davis, California 95616, USA
Ronald J. Baskin: University of California, Davis, California 95616, USA
Stephen C. Kowalczykowski: University of California, Davis, California 95616, USA

Nature, 2013, vol. 500, issue 7463, 482-485

Abstract: The bacterial RecBCD helicase/nuclease shows broad, and apparently static, heterogeneity in the unwinding rate manifest by individual molecules: here it is shown that transiently halting an enzyme during processive translocation allows for a change, most likely conformational, such that the velocity of the molecule after pausing can fall anywhere within the spectrum of rates seen for a population.

Date: 2013
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DOI: 10.1038/nature12333

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