Charting a dynamic DNA methylation landscape of the human genome

Michael J. Ziller, Hongcang Gu, Fabian Müller, Julie Donaghey, Linus T.-Y. Tsai, Oliver Kohlbacher, Philip L. De Jager, Evan D. Rosen, David A. Bennett, Bradley E. Bernstein, Andreas Gnirke and Alexander Meissner ()
Additional contact information
Michael J. Ziller: Broad Institute of MIT and Harvard
Hongcang Gu: Broad Institute of MIT and Harvard
Fabian Müller: Harvard University
Julie Donaghey: Broad Institute of MIT and Harvard
Linus T.-Y. Tsai: Beth Israel Deaconess Medical Center
Oliver Kohlbacher: Applied Bioinformatics, Center for Bioinformatics and Quantitative Biology Center, University of Tübingen, 72074 Tübingen, Germany
Philip L. De Jager: Broad Institute of MIT and Harvard
Evan D. Rosen: Broad Institute of MIT and Harvard
David A. Bennett: Rush Alzheimer’s Disease Center, Rush University Medical Center, 600 South Paulina Street, Chicago, Illinois 60612, USA
Bradley E. Bernstein: Broad Institute of MIT and Harvard
Andreas Gnirke: Broad Institute of MIT and Harvard
Alexander Meissner: Broad Institute of MIT and Harvard

Nature, 2013, vol. 500, issue 7463, 477-481

Abstract: Whole-genome bisulphite sequencing data from diverse human cell and tissue types shows that only about 22% of CpGs change their methylation state across these cell types; most of these CpGs are located at gene regulatory elements, particularly enhancers and transcription-factor-binding sites, and these selected regions with dynamic DNA methylation patterns could help to define putative regulatory elements further.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature12433 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:500:y:2013:i:7463:d:10.1038_nature12433

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12433

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().