Optical control of mammalian endogenous transcription and epigenetic states

Silvana Konermann, Mark D. Brigham, Alexandro E. Trevino, Patrick D. Hsu, Matthias Heidenreich, Le Cong, Randall J. Platt, David A. Scott, George M. Church and Feng Zhang ()
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Silvana Konermann: Broad Institute of MIT and Harvard, 7 Cambridge Center
Mark D. Brigham: Broad Institute of MIT and Harvard, 7 Cambridge Center
Alexandro E. Trevino: Broad Institute of MIT and Harvard, 7 Cambridge Center
Patrick D. Hsu: Broad Institute of MIT and Harvard, 7 Cambridge Center
Matthias Heidenreich: Broad Institute of MIT and Harvard, 7 Cambridge Center
Le Cong: Broad Institute of MIT and Harvard, 7 Cambridge Center
Randall J. Platt: Broad Institute of MIT and Harvard, 7 Cambridge Center
David A. Scott: Broad Institute of MIT and Harvard, 7 Cambridge Center
George M. Church: Broad Institute of MIT and Harvard, 7 Cambridge Center
Feng Zhang: Broad Institute of MIT and Harvard, 7 Cambridge Center

Nature, 2013, vol. 500, issue 7463, 472-476

Abstract: Here the customizable TALE DNA-binding domain was integrated with the light-sensitive cryptochrome 2 protein and its interacting partner (CIB1) from Arabidopsis thaliana, thereby creating an optogenetic two-hybrid system called light-inducible transcriptional effectors (LITEs); the LITE system establishes a novel mode of optogenetic control of endogenous transcription and epigenetic states.

Date: 2013
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DOI: 10.1038/nature12466

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