Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations

Gregory I. Lang (), Daniel P. Rice, Mark J. Hickman, Erica Sodergren, George M. Weinstock, David Botstein and Michael M. Desai ()
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Gregory I. Lang: Princeton University
Daniel P. Rice: and FAS Center for Systems Biology, Harvard University
Mark J. Hickman: Rowan University
Erica Sodergren: The Genome Institute, Washington University School of Medicine
George M. Weinstock: The Genome Institute, Washington University School of Medicine
David Botstein: Princeton University
Michael M. Desai: and FAS Center for Systems Biology, Harvard University

Nature, 2013, vol. 500, issue 7464, 571-574

Abstract: Whole-genome whole-population sequencing is used to examine the dynamics of genome-sequence evolution in Saccharomyces cerevisiae populations for 1,000 generations; this reveals patterns of sequence evolution driven by pervasive genetic hitchhiking and interference, and shows that beneficial mutations that escape drift and increase in frequency typically occur in cohorts.

Date: 2013
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DOI: 10.1038/nature12344

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