Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor

Tien Peng, Ying Tian, Cornelis J. Boogerd, Min Min Lu, Rachel S. Kadzik, Kathleen M. Stewart, Sylvia M. Evans and Edward E. Morrisey ()
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Tien Peng: Perelman School of Medicine at the University of Pennsylvania
Ying Tian: Perelman School of Medicine at the University of Pennsylvania
Cornelis J. Boogerd: Skaggs School of Pharmacy, University of California, San Diego, San Diego, California 92093, USA
Min Min Lu: Cardiovascular Institute, University of Pennsylvania
Rachel S. Kadzik: Perelman School of Medicine at the University of Pennsylvania
Kathleen M. Stewart: Perelman School of Medicine at the University of Pennsylvania
Sylvia M. Evans: Skaggs School of Pharmacy, University of California, San Diego, San Diego, California 92093, USA
Edward E. Morrisey: Perelman School of Medicine at the University of Pennsylvania

Nature, 2013, vol. 500, issue 7464, 589-592

Abstract: A population of multipotent cardiopulmonary mesoderm progenitors (CPPs) within the posterior pole of the heart expresses Wnt2, Gli1 and Isl1; these CPPs arise from cardiac progenitors before lung development, generate the mesoderm lineages within the cardiac inflow tract and lung, and are regulated by hedgehog expression from the foregut endoderm.

Date: 2013
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DOI: 10.1038/nature12358

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