Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing

Zhigang Xue (), Kevin Huang, Chaochao Cai, Lingbo Cai, Chun-yan Jiang, Yun Feng, Zhenshan Liu, Qiao Zeng, Liming Cheng, Yi E. Sun, Jia-yin Liu (), Steve Horvath and Guoping Fan ()
Additional contact information
Zhigang Xue: Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine
Kevin Huang: David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
Chaochao Cai: David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
Lingbo Cai: State Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University
Chun-yan Jiang: State Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University
Yun Feng: Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine
Zhenshan Liu: Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine
Qiao Zeng: Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine
Liming Cheng: Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine
Yi E. Sun: Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine
Jia-yin Liu: State Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University
Steve Horvath: David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
Guoping Fan: David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA

Nature, 2013, vol. 500, issue 7464, 593-597

Abstract: Single-cell RNA sequencing and weighted gene co-expression network analysis are used to study transcriptome change in pre-implantation embryos and oocytes; this reveals a conserved genetic program between human and mouse but with different developmental specificity and timing, and conserved hub genes that may be key in pre-implantation development.

Date: 2013
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DOI: 10.1038/nature12364

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