lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs

Liuqing Yang (), Chunru Lin (), Chunyu Jin, Joy C. Yang, Bogdan Tanasa, Wenbo Li, Daria Merkurjev, Kenneth A. Ohgi, Da Meng, Jie Zhang, Christopher P. Evans and Michael G. Rosenfeld ()
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Liuqing Yang: Howard Hughes Medical Institute, University of California San Diego
Chunru Lin: Howard Hughes Medical Institute, University of California San Diego
Chunyu Jin: Howard Hughes Medical Institute, University of California San Diego
Joy C. Yang: School of Medicine, University of California Davis
Bogdan Tanasa: Howard Hughes Medical Institute, University of California San Diego
Wenbo Li: Howard Hughes Medical Institute, University of California San Diego
Daria Merkurjev: Howard Hughes Medical Institute, University of California San Diego
Kenneth A. Ohgi: Howard Hughes Medical Institute, University of California San Diego
Da Meng: Neurosciences Graduate Program, University of California San Diego
Jie Zhang: Howard Hughes Medical Institute, University of California San Diego
Christopher P. Evans: School of Medicine, University of California Davis
Michael G. Rosenfeld: Howard Hughes Medical Institute, University of California San Diego

Nature, 2013, vol. 500, issue 7464, 598-602

Abstract: A study of prostate cancer cells reveals a transcriptional activation role for long non-coding RNAs (PRNCR1 and PCGEM1) that bind to the androgen receptor, and is also observed for the truncated androgen receptor characteristic of many aggressive prostate cancers.

Date: 2013
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DOI: 10.1038/nature12451

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