Prolonged dopamine signalling in striatum signals proximity and value of distant rewards
Mark W. Howe,
Patrick L. Tierney,
Stefan G. Sandberg,
Paul E. M. Phillips and
Ann M. Graybiel ()
Additional contact information
Mark W. Howe: Massachusetts Institute of Technology
Patrick L. Tierney: Massachusetts Institute of Technology
Stefan G. Sandberg: University of Washington
Paul E. M. Phillips: University of Washington
Ann M. Graybiel: Massachusetts Institute of Technology
Nature, 2013, vol. 500, issue 7464, 575-579
Abstract:
Cyclic voltammetry reveals an extended mode of reward-predictive dopamine signalling in the striatum as rats navigate; signals increase as the rats approach distant rewards, instead of showing phasic or steady tonic activity, and the increases scale flexibly with the distance and size of the rewards.
Date: 2013
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DOI: 10.1038/nature12475
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