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Prolonged dopamine signalling in striatum signals proximity and value of distant rewards

Mark W. Howe, Patrick L. Tierney, Stefan G. Sandberg, Paul E. M. Phillips and Ann M. Graybiel ()
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Mark W. Howe: Massachusetts Institute of Technology
Patrick L. Tierney: Massachusetts Institute of Technology
Stefan G. Sandberg: University of Washington
Paul E. M. Phillips: University of Washington
Ann M. Graybiel: Massachusetts Institute of Technology

Nature, 2013, vol. 500, issue 7464, 575-579

Abstract: Cyclic voltammetry reveals an extended mode of reward-predictive dopamine signalling in the striatum as rats navigate; signals increase as the rats approach distant rewards, instead of showing phasic or steady tonic activity, and the increases scale flexibly with the distance and size of the rewards.

Date: 2013
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DOI: 10.1038/nature12475

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