Recovery from slow inactivation in K+ channels is controlled by water molecules

Jared Ostmeyer, Sudha Chakrapani, Albert C. Pan, Eduardo Perozo and Benoît Roux ()
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Jared Ostmeyer: The University of Chicago, 929 E57th Street, Chicago, Illinois 60637, USA
Sudha Chakrapani: School of Medicine, Case Western Reserve University
Albert C. Pan: The University of Chicago, 929 E57th Street, Chicago, Illinois 60637, USA
Eduardo Perozo: The University of Chicago, 929 E57th Street, Chicago, Illinois 60637, USA
Benoît Roux: The University of Chicago, 929 E57th Street, Chicago, Illinois 60637, USA

Nature, 2013, vol. 501, issue 7465, 121-124

Abstract: A series of long molecular dynamics simulations shows that the K+ channel is sterically locked in the inactive conformation by buried water molecules bound behind the selectivity filter; a kinetic model deduced from the simulations shows how releasing the buried waters can elongate the timescale of the recovery period, and this hypothesis is confirmed using ‘wet’ biophysical experiments.

Date: 2013
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DOI: 10.1038/nature12395

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