The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein

Tiziana Sonati, Regina R. Reimann, Jeppe Falsig, Pravas Kumar Baral, Tracy O’Connor, Simone Hornemann, Sine Yaganoglu, Bei Li, Uli S. Herrmann, Barbara Wieland, Mridula Swayampakula, Muhammad Hafizur Rahman, Dipankar Das, Nat Kav, Roland Riek, Pawel P. Liberski, Michael N. G. James and Adriano Aguzzi ()
Additional contact information
Tiziana Sonati: Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland
Regina R. Reimann: Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland
Jeppe Falsig: Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland
Pravas Kumar Baral: Faculty of Medicine & Dentistry, University of Alberta 474 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada
Tracy O’Connor: Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland
Simone Hornemann: Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland
Sine Yaganoglu: Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland
Bei Li: Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland
Uli S. Herrmann: Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland
Barbara Wieland: Faculty of Medicine & Dentistry, University of Alberta 474 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada
Mridula Swayampakula: Faculty of Medicine & Dentistry, University of Alberta 474 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada
Muhammad Hafizur Rahman: Food and Nutritional Science, University of Alberta, 410 Agriculture/Forestry Centre, Edmonton, Alberta T6G 2P5, Canada
Dipankar Das: Food and Nutritional Science, University of Alberta, 410 Agriculture/Forestry Centre, Edmonton, Alberta T6G 2P5, Canada
Nat Kav: Food and Nutritional Science, University of Alberta, 410 Agriculture/Forestry Centre, Edmonton, Alberta T6G 2P5, Canada
Roland Riek: ETH Zurich, Physical Chemistry, ETH Hönggerberg, Wolfgang-Pauli-Strasse 10, CH-8093 Zurich, Switzerland
Pawel P. Liberski: Laboratory of Electron Microscopy and Neuropathology, Medical University of Lodz, Czechoslowacka 8/10, 92-216 Lodz, Poland
Michael N. G. James: Faculty of Medicine & Dentistry, University of Alberta 474 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada
Adriano Aguzzi: Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland

Nature, 2013, vol. 501, issue 7465, 102-106

Abstract: Biochemical and structural investigation of a model for prion-induced neurodegeneration—antibody binding to PrPC—reveals the role of the PrP flexible tail and reactive oxygen species in mediating toxicity.

Date: 2013
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DOI: 10.1038/nature12402

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