Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection

Wei-Jie Zhou, Zhen H. Geng, Jason R. Spence and Jian-Guo Geng ()
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Wei-Jie Zhou: University of Michigan School of Dentistry
Zhen H. Geng: University of Michigan School of Dentistry
Jason R. Spence: University of Michigan School of Medicine
Jian-Guo Geng: University of Michigan School of Dentistry

Nature, 2013, vol. 501, issue 7465, 107-111

Abstract: Evidence of crosstalk between the Robo/Slit and Wnt signalling pathways is provided, and R-spondin signalling is shown to enhance canonical Wnt signalling and increase the proliferation of intestinal stem cells.

Date: 2013
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DOI: 10.1038/nature12416

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