Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi

Giovanni D’Angelo, Takefumi Uemura, Chia-Chen Chuang, Elena Polishchuk, Michele Santoro, Henna Ohvo-Rekilä, Takashi Sato, Giuseppe Di Tullio, Antonio Varriale, Sabato D’Auria, Tiziana Daniele, Fabrizio Capuani, Ludger Johannes, Peter Mattjus, Maria Monti, Piero Pucci, Roger L. Williams, John E. Burke, Frances M. Platt, Akihiro Harada and Maria Antonietta De Matteis ()
Additional contact information
Giovanni D’Angelo: Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy
Takefumi Uemura: Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan
Chia-Chen Chuang: University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Elena Polishchuk: Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy
Michele Santoro: Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy
Henna Ohvo-Rekilä: Biochemistry, Åbo Akademi University, Artillerigatan 6 A III, BioCity, FI-20520 Turku, Finland
Takashi Sato: Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan
Giuseppe Di Tullio: Consorzio Mario Negri Sud, Via Nazionale 8/A, 66030 Santa Maria Imbaro, Chieti, Italy
Antonio Varriale: Institute of Protein Biochemistry National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy
Sabato D’Auria: Institute of Protein Biochemistry National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy
Tiziana Daniele: Consorzio Mario Negri Sud, Via Nazionale 8/A, 66030 Santa Maria Imbaro, Chieti, Italy
Fabrizio Capuani: Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy
Ludger Johannes: Institut Curie Centre de Recherche, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Peter Mattjus: Biochemistry, Åbo Akademi University, Artillerigatan 6 A III, BioCity, FI-20520 Turku, Finland
Maria Monti: Università di Napoli FedericoII, ViaGaetano Salvatore 482, 80145 Napoli, Italy
Piero Pucci: Università di Napoli FedericoII, ViaGaetano Salvatore 482, 80145 Napoli, Italy
Roger L. Williams: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
John E. Burke: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Frances M. Platt: University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Akihiro Harada: Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan
Maria Antonietta De Matteis: Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy

Nature, 2013, vol. 501, issue 7465, 116-120

Abstract: Glucosylceramide (GlcCer), a common precursor of different glycosphingolipids, is shown to be channelled to two distinct pathways in the Golgi; non-vesicular transport from the cis- to trans-Golgi network results in the synthesis of the globo series of glycosphingolipids, whereas vesicular transport is the main source of GlcCer for ganglioside synthesis in the Golgi cisternae.

Date: 2013
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature12423 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:501:y:2013:i:7465:d:10.1038_nature12423

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12423

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().