Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

Mathias Jucker () and Lary C. Walker ()
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Mathias Jucker: Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany
Lary C. Walker: Yerkes National Primate Research Center, Emory University

Nature, 2013, vol. 501, issue 7465, 45-51

Abstract: The prion paradigm – the hypothesis that the seeded aggregation of certain proteins is key to understanding age-related neurodegenerative disorders – is evaluated in relation to recent studies and disease models; the paradigm suggests a unifying pathogenic principle with broad relevance to a large class of currently intractable diseases.

Date: 2013
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DOI: 10.1038/nature12481

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