Microbial colonization influences early B-lineage development in the gut lamina propria

Duane R. Wesemann (), Andrew J. Portuguese, Robin M. Meyers, Michael P. Gallagher, Kendra Cluff-Jones, Jennifer M. Magee, Rohit A. Panchakshari, Scott J. Rodig, Thomas B. Kepler and Frederick W. Alt ()
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Duane R. Wesemann: Children’s Hospital Boston, Boston, Massachusetts 02115, USA
Andrew J. Portuguese: Children’s Hospital Boston, Boston, Massachusetts 02115, USA
Robin M. Meyers: Children’s Hospital Boston, Boston, Massachusetts 02115, USA
Michael P. Gallagher: Children’s Hospital Boston, Boston, Massachusetts 02115, USA
Kendra Cluff-Jones: Children’s Hospital Boston, Boston, Massachusetts 02115, USA
Jennifer M. Magee: Children’s Hospital Boston, Boston, Massachusetts 02115, USA
Rohit A. Panchakshari: Children’s Hospital Boston, Boston, Massachusetts 02115, USA
Scott J. Rodig: Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA
Thomas B. Kepler: Boston University School of Medicine, Boston, Massachusetts 02215, USA
Frederick W. Alt: Children’s Hospital Boston, Boston, Massachusetts 02115, USA

Nature, 2013, vol. 501, issue 7465, 112-115

Abstract: Primary B-cell development is thought to be restricted to the bone marrow; here it is shown to occur also in intestinal tissues of postnatal mice, that it peaks at the time of weaning and is increased upon colonization of germ-free mice, and is thus influenced by commensal microbes.

Date: 2013
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DOI: 10.1038/nature12496

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