Induction of mouse germ-cell fate by transcription factors in vitro

Fumio Nakaki, Katsuhiko Hayashi, Hiroshi Ohta, Kazuki Kurimoto, Yukihiro Yabuta and Mitinori Saitou ()
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Fumio Nakaki: Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
Katsuhiko Hayashi: Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
Hiroshi Ohta: Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
Kazuki Kurimoto: Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
Yukihiro Yabuta: Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
Mitinori Saitou: Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan

Nature, 2013, vol. 501, issue 7466, 222-226

Abstract: Expression of the three transcription factors BLIMP1, PRDM14 and TFAP2C, or of PRDM14 alone, converts epiblast-like cells into primordial germ cell (PGC)-like cells; the transcription-factor-induced PGC-like cells acquire key transcriptome and epigenetic reprogramming in PGCs, and contribute to spermatogenesis and fertile offspring.

Date: 2013
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DOI: 10.1038/nature12417

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