The pluripotent genome in three dimensions is shaped around pluripotency factors

Elzo de Wit, Britta A. M. Bouwman, Yun Zhu, Petra Klous, Erik Splinter, Marjon J. A. M. Verstegen, Peter H. L. Krijger, Nicola Festuccia, Elphège P. Nora, Maaike Welling, Edith Heard, Niels Geijsen, Raymond A. Poot, Ian Chambers and Wouter de Laat ()
Additional contact information
Elzo de Wit: Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Britta A. M. Bouwman: Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Yun Zhu: Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Petra Klous: Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Erik Splinter: Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Marjon J. A. M. Verstegen: Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Peter H. L. Krijger: Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Nicola Festuccia: MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK
Elphège P. Nora: Mammalian Developmental Epigenetics Group, Institut Curie CNRS UMR3215 INSERM U934
Maaike Welling: Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Edith Heard: Mammalian Developmental Epigenetics Group, Institut Curie CNRS UMR3215 INSERM U934
Niels Geijsen: Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Raymond A. Poot: Erasmus Medical Center
Ian Chambers: MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK
Wouter de Laat: Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands

Nature, 2013, vol. 501, issue 7466, 227-231

Abstract: Using 4C technology, higher-order topological features of the pluripotent genome are identified; in pluripotent stem cells, Nanog clusters specifically with other pluripotency genes and this clustering is centred around Nanog-binding sites, suggesting that Nanog helps to shape the three-dimensional structure of the pluripotent genome and thereby contributes to the robustness of the pluripotent state.

Date: 2013
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DOI: 10.1038/nature12420

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